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type ii collagen ctx ii  (Thermo Fisher)


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    Structured Review

    Thermo Fisher type ii collagen ctx ii
    Study protocol schematic. ACL, anterior cruciate ligament; ALM, adenosine, lidocaine, and magnesium therapy; <t>CTX-II,</t> <t>C-terminal</t> cross-linked telopeptide of type II collagen; d, days; IA, intra-articular; IV, intravenous.
    Type Ii Collagen Ctx Ii, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/type ii collagen ctx ii/product/Thermo Fisher
    Average 99 stars, based on 1 article reviews
    type ii collagen ctx ii - by Bioz Stars, 2026-06
    99/100 stars

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    1) Product Images from "Adenosine, lidocaine, and magnesium therapy augments joint tissue healing following experimental anterior cruciate ligament rupture and reconstruction"

    Article Title: Adenosine, lidocaine, and magnesium therapy augments joint tissue healing following experimental anterior cruciate ligament rupture and reconstruction

    Journal: Bone & Joint Research

    doi: 10.1302/2046-3758.136.BJR-2023-0360.R1

    Study protocol schematic. ACL, anterior cruciate ligament; ALM, adenosine, lidocaine, and magnesium therapy; CTX-II, C-terminal cross-linked telopeptide of type II collagen; d, days; IA, intra-articular; IV, intravenous.
    Figure Legend Snippet: Study protocol schematic. ACL, anterior cruciate ligament; ALM, adenosine, lidocaine, and magnesium therapy; CTX-II, C-terminal cross-linked telopeptide of type II collagen; d, days; IA, intra-articular; IV, intravenous.

    Techniques Used:

    Cartilage degenerative changes in male and female adenosine, lidocaine, and magnesium (ALM)-treated and Saline control animals, 28 days after anterior cruciate ligament reconstruction (ACLR) surgery. a) Postoperative urinary CTX-II levels peaked in the first postoperative week, and were higher in females than males. b) Osteoarthritis Research Society International (OARSI) scoring of medial articular cartilage surfaces, and c) representative safranin O/fast green-stained sections (magnification ×100) of medial femoral condyles (MFC, upper panels) and medial tibial plateau (MTP, lower panels). Minor proteoglycan loss (asterisk), and surface fibrillation (arrows) was evident, with no sex- or treatment-specific differences. d) Relative expression of cartilage extracellular matrix (ECM) components (collagen type 2, Col2a1; aggrecan, Acan), ECM remodelling enzymes (matrix metalloproteinase-13, MMP13; tissue inhibitor of matrix metalloproteinase 1, Timp1); and mediators of cell proliferation and activation (transforming growth factor β 1, Tgfb1; α smooth muscle actin, Acta2) in MFC cartilage. MMP13 levels were higher in males than females, with ALM dampening this response. In females, expression of Acan, Tgfb1, and Acta2 was increased in ALM-treated, than Saline control animals. e) Representative α-SMA-stained sections of MFC indicating the presence of positive-staining cells in the superficial and transitional zones (arrowheads) of ALM-treated animals. Data show medians and interquartile ranges. *p < 0.05, Kruskal–Wallis test.
    Figure Legend Snippet: Cartilage degenerative changes in male and female adenosine, lidocaine, and magnesium (ALM)-treated and Saline control animals, 28 days after anterior cruciate ligament reconstruction (ACLR) surgery. a) Postoperative urinary CTX-II levels peaked in the first postoperative week, and were higher in females than males. b) Osteoarthritis Research Society International (OARSI) scoring of medial articular cartilage surfaces, and c) representative safranin O/fast green-stained sections (magnification ×100) of medial femoral condyles (MFC, upper panels) and medial tibial plateau (MTP, lower panels). Minor proteoglycan loss (asterisk), and surface fibrillation (arrows) was evident, with no sex- or treatment-specific differences. d) Relative expression of cartilage extracellular matrix (ECM) components (collagen type 2, Col2a1; aggrecan, Acan), ECM remodelling enzymes (matrix metalloproteinase-13, MMP13; tissue inhibitor of matrix metalloproteinase 1, Timp1); and mediators of cell proliferation and activation (transforming growth factor β 1, Tgfb1; α smooth muscle actin, Acta2) in MFC cartilage. MMP13 levels were higher in males than females, with ALM dampening this response. In females, expression of Acan, Tgfb1, and Acta2 was increased in ALM-treated, than Saline control animals. e) Representative α-SMA-stained sections of MFC indicating the presence of positive-staining cells in the superficial and transitional zones (arrowheads) of ALM-treated animals. Data show medians and interquartile ranges. *p < 0.05, Kruskal–Wallis test.

    Techniques Used: Saline, Control, Staining, Expressing, Activation Assay



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    Image Search Results


    Study protocol schematic. ACL, anterior cruciate ligament; ALM, adenosine, lidocaine, and magnesium therapy; CTX-II, C-terminal cross-linked telopeptide of type II collagen; d, days; IA, intra-articular; IV, intravenous.

    Journal: Bone & Joint Research

    Article Title: Adenosine, lidocaine, and magnesium therapy augments joint tissue healing following experimental anterior cruciate ligament rupture and reconstruction

    doi: 10.1302/2046-3758.136.BJR-2023-0360.R1

    Figure Lengend Snippet: Study protocol schematic. ACL, anterior cruciate ligament; ALM, adenosine, lidocaine, and magnesium therapy; CTX-II, C-terminal cross-linked telopeptide of type II collagen; d, days; IA, intra-articular; IV, intravenous.

    Article Snippet: C-terminal cross-linked telopeptide of type II collagen (CTX-II), a marker of cartilage degradation, was measured in urine collected at day -1, 3, 8, and 28 following surgery (Rat CTX-II ELISA kit, E-EL-R2554; Elabscience, USA), and normalized to urinary creatinine (Creatinine Urinary Detection Kit, EIACUN; Thermo Fisher Scientific, USA), according to manufacturer’s instructions.

    Techniques:

    Cartilage degenerative changes in male and female adenosine, lidocaine, and magnesium (ALM)-treated and Saline control animals, 28 days after anterior cruciate ligament reconstruction (ACLR) surgery. a) Postoperative urinary CTX-II levels peaked in the first postoperative week, and were higher in females than males. b) Osteoarthritis Research Society International (OARSI) scoring of medial articular cartilage surfaces, and c) representative safranin O/fast green-stained sections (magnification ×100) of medial femoral condyles (MFC, upper panels) and medial tibial plateau (MTP, lower panels). Minor proteoglycan loss (asterisk), and surface fibrillation (arrows) was evident, with no sex- or treatment-specific differences. d) Relative expression of cartilage extracellular matrix (ECM) components (collagen type 2, Col2a1; aggrecan, Acan), ECM remodelling enzymes (matrix metalloproteinase-13, MMP13; tissue inhibitor of matrix metalloproteinase 1, Timp1); and mediators of cell proliferation and activation (transforming growth factor β 1, Tgfb1; α smooth muscle actin, Acta2) in MFC cartilage. MMP13 levels were higher in males than females, with ALM dampening this response. In females, expression of Acan, Tgfb1, and Acta2 was increased in ALM-treated, than Saline control animals. e) Representative α-SMA-stained sections of MFC indicating the presence of positive-staining cells in the superficial and transitional zones (arrowheads) of ALM-treated animals. Data show medians and interquartile ranges. *p < 0.05, Kruskal–Wallis test.

    Journal: Bone & Joint Research

    Article Title: Adenosine, lidocaine, and magnesium therapy augments joint tissue healing following experimental anterior cruciate ligament rupture and reconstruction

    doi: 10.1302/2046-3758.136.BJR-2023-0360.R1

    Figure Lengend Snippet: Cartilage degenerative changes in male and female adenosine, lidocaine, and magnesium (ALM)-treated and Saline control animals, 28 days after anterior cruciate ligament reconstruction (ACLR) surgery. a) Postoperative urinary CTX-II levels peaked in the first postoperative week, and were higher in females than males. b) Osteoarthritis Research Society International (OARSI) scoring of medial articular cartilage surfaces, and c) representative safranin O/fast green-stained sections (magnification ×100) of medial femoral condyles (MFC, upper panels) and medial tibial plateau (MTP, lower panels). Minor proteoglycan loss (asterisk), and surface fibrillation (arrows) was evident, with no sex- or treatment-specific differences. d) Relative expression of cartilage extracellular matrix (ECM) components (collagen type 2, Col2a1; aggrecan, Acan), ECM remodelling enzymes (matrix metalloproteinase-13, MMP13; tissue inhibitor of matrix metalloproteinase 1, Timp1); and mediators of cell proliferation and activation (transforming growth factor β 1, Tgfb1; α smooth muscle actin, Acta2) in MFC cartilage. MMP13 levels were higher in males than females, with ALM dampening this response. In females, expression of Acan, Tgfb1, and Acta2 was increased in ALM-treated, than Saline control animals. e) Representative α-SMA-stained sections of MFC indicating the presence of positive-staining cells in the superficial and transitional zones (arrowheads) of ALM-treated animals. Data show medians and interquartile ranges. *p < 0.05, Kruskal–Wallis test.

    Article Snippet: C-terminal cross-linked telopeptide of type II collagen (CTX-II), a marker of cartilage degradation, was measured in urine collected at day -1, 3, 8, and 28 following surgery (Rat CTX-II ELISA kit, E-EL-R2554; Elabscience, USA), and normalized to urinary creatinine (Creatinine Urinary Detection Kit, EIACUN; Thermo Fisher Scientific, USA), according to manufacturer’s instructions.

    Techniques: Saline, Control, Staining, Expressing, Activation Assay